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rabbit polyclonal anti brca1 ser1387  (Novus Biologicals)


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    Structured Review

    Novus Biologicals rabbit polyclonal anti brca1 ser1387
    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
    Rabbit Polyclonal Anti Brca1 Ser1387, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit polyclonal anti brca1 ser1387/product/Novus Biologicals
    Average 93 stars, based on 2 article reviews
    rabbit polyclonal anti brca1 ser1387 - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate"

    Article Title: Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate

    Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    doi: 10.33594/000000562

    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker BRCA1, and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
    Figure Legend Snippet: NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker BRCA1, and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.

    Techniques Used: Staining, Marker, Derivative Assay



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    rabbit polyclonal anti brca1 ser1387  (Novus Biologicals)
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
    Rabbit Polyclonal Anti Brca1 Ser1387, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    rabbit polyclonal anti brca 1  (Proteintech)
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    Image Search Results


    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker BRCA1, and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.

    Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    Article Title: Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate

    doi: 10.33594/000000562

    Figure Lengend Snippet: NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker BRCA1, and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.

    Article Snippet: Primary antibodies used to stain DNA repair proteins are as follows: mouse monoclonal anti-γH2AX-phosphoSer139 (Milli-pore [clone JBW301] 05–636; dilution 1:1000), rabbit polyclonal anti-BRCA1 (Ser1387) (Novus Biologicals, NB100–225SS; dilution 1:250), and mouse monoclonal anti-DNA-PKcs (phospho-Thr2609) (Abcam, ab18356; dilution 1:250).

    Techniques: Staining, Marker, Derivative Assay